Features
The majority of the clinical uses for CoQ10 are founded upon its role as an antioxidant, and its role in mitochondrial bioenergetics. It is a coenzyme for numerous reactions involved in cellular respiration, and is required for the efficient formation of adenosine triphosphate (ATP), the cellular currency which drives the majority of enzymatic reactions. It inhibits peroxidation of cell membrane lipids and as well as circulating lipoproteins. CoQ10 supports cardiac tissues by improving endothelial function and by having a direct anti-atherogenic effect, which results in lower blood pressure and improved ventricular contractility.
High dose CoQ10, ranging up to 2,400 mg per day, has been used primarily for neurodegenerative diseases such as Parkinson’s and Huntington’s disease, though elevated doses have also been used in patients with severe cardiovascular disease or advanced breast cancer. Clinical trials have shown benefit for a wide range of cardiovascular conditions, including congestive heart failure, hypertension, and prevention of myocardial infarction. It has also had clinical benefit for a number of other conditions, including migraine, periodontal disease, gingivitis, male infertility, and statin-induced myopathy.
Benefits
- Identical to the form produced by the human body for high bioavailability
- Improves many varied health conditions, including cardiovascular disease, cellular decomposition and oxidative stress
- Higher dosage of 400 mg reduces the need of taking multiple pills during the day and keeps pace with the research
- Free of contamination by undesirable residue or micro-organisms, including bacteria or yeast
- In a base of natural ricebran oil and vitamin E to ensure a stabilized and highly absorbable form of CoQ10
Ingredients
Serving Size: 1 softgel
Servings per Container: 30
1 Softgel Provides:
Coenzyme Q10 (Ubiquinone)...........................................................................400 mg
Other Ingredients: Rice bran oil, softgel capsule (gelatin, glycerin, purified water, carob), natural vitamin E.
Dosage
1 softgel per day or as directed by a health care professional.
Contraindications
While no specific contraindications exist or are predicted, data is lacking for use during pregnancy, lactation, and in children, and the dosage may need to be reduced for those less than 18.
Additional Information
Drug Interactions: Although very little evidence supports this interaction, CoQ10 resembles vitamin K structurally, and a potential interaction is possible for those taking the anticoagulant Coumadin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients.
No other negative drug interactions are known for CoQ10, though a number of medications are thought to interfere with CoQ10 synthesis or function in the body, including statin medications, tricyclic antidepressants, and oral hypoglycemic agents. To prevent side effects or the depletion of CoQ10 in body tissues, many health experts recommend supplementing CoQ10 at dosages ranging from 30 to 400 mg per day in people taking the following drugs:
- Cholesterol lowering drugs, such as atorvastatin (Lipitor); gemfibrozil (Lopid); lovastatin (Mevacor); pravastatin (Pravachol); simvastatin (Zocor), etc.
- Beta-blocker drugs used in angina, high blood pressure, and heart arrhythmias, such as acebutolol (Sectral); atenolol (Tenormin); carteolol (Cartrol); metoprolol (Lopressor, Toprol XL); penbutolol (Levatol); propanolol (Inderal); timolol (Blocarden), etc.
- Phenothiazine drugs used in various psychiatric disorders such as chlorpromazine (Thorazine); fluphenazine (Permitil, Prolixin); mesoridazine (Serentil); trifluoperazine (Stelazine); etc.
- Tricyclic antidepressants, such as amitryptaline (Elavil, Endep); desipramine (Norpramin, Pertofrane); doxepin (Adapin, Sinequan); imipramine (Imavate, Presamine, Trofinil); nortryptaline (Aventyl, Pamelor); protryptaline (Vivactil); etc.
Product contains no: artificial preservatives or sweeteners; no corn, dairy, gluten, starch or wheat.