Have you ever wondered why PharmaGABA is superior to synthetic GABA? Dr. Murray explains.
Confusion over GABA has prevented this supplement from finding it's true place in stress management protocols. Dr. Murray's article, "PharmaGABA: Natural Support for Stress, Anxiety and Insomnia" explores the science behind PharmaGABA, its superiority over synthetic GABA and how it can be a useful tool.
An excerpt from the article:
INTRODUCTION
Gamma-aminobutyric acid (GABA) is a major neurotransmitter that is abundantly and widely distributed throughout the central nervous system (CNS). Within the brain, GABA is formed in neuronal cells by the a-decarboxylation of glutamic acid and further metabolized by GABA-a-keto-glutarate transaminase and then returned to the tricarboxylic acid cycle (TCA) cycle. Plasma membrane depolarization induces the release of GABA from the nerve terminals and GABA binds to GABA receptors, such as the GABAA receptor and the GABAB receptor, which are distributed on the post-synaptic cell membranes. Among other effects, GABA is known to mediate pre-synaptic inhibition of primary afferent fibers in the motor system and may also be involved in post-synaptic forms of motor neuron inhibition.
The neurotransmitter actions of GABA in the synaptic cleft are terminated by its reuptake by either pre-synaptic neurons or nearby glial cells via specific and high-affinity transporters that are believed to be the major mechanism for reducing its concentration in the extracellular fluid within the brain.
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