Dr. Pizzorno lends his expertise to the insight behind the Clear-HM product
Below is a segment of the Clear-HM Product Insight:
Advanced Heavy Metal Detoxification Support
Heavy metal toxicity is a growing problem which has far-reaching consequences, ranging from subtle neurodevelopmental effects in children, to more clinically apparent disease in adults, such as osteoporosis, myocardial infarction, neurodegeneration and hypertension.1,2,3,4,5 Indeed, the clinical importance of heavy metal toxicity is likely to be greatly underestimated, as evidenced by a study of over 800 men with supposedly low blood lead levels which documented more than a 5-fold risk for cardiovascular mortality, and over an 8-fold risk for ischemic heart disease mortality when bone lead was measured.6 This study clearly highlights the risk of chronic low dose toxicity from heavy metals, as well as the inability of standard screening tests (i.e. blood lead levels) to detect relevant exposure.
We designed Clear-HM to provide functional support for heavy metal detoxifi cation, supplying nutrients needed to assist not only in heavy metal removal, but also to replenish competing minerals often depleted by chelation therapy, and to provide antioxidant protection from the reactive oxygen species which mediate much of the heavy metal damage. We also chose nutrients which would increase intracellular levels of glutathione, a key nutrient for heavy metal detoxifi cation, as well as the elimination of many persistent organic pollutants.
Glutathione Synthesis
Glutathione depletion, caused by heavy metals and other environmental toxins, plays an important role in the pathophysiology of many human conditions.7 At the suggested dose, Clear-HM provides roughly 400 mg alpha-lipoic acid (ALA), and 333 mg N-acetylcysteine (NAC), two nutrients proven to increase endogenous synthesis of glutathione, in addition to directly reducing the toxicity of many environmental substances.8,9 Recent data suggests that NAC-induced de novo synthesis of glutathione is more critical to mitigating heavy metal toxicity than is the pre-existing extracellular glutathione.10 NAC has also been shown to provide antioxidant protection against lead, cadmium, and arsenic exposure, and dose-dependently increase the urinary excretion of methylmercury in animal studies.11,12,13 In addition to stimulating glutathione synthesis, lipoic acid has been shown to provide protection against both neuronal and hepatic heavy metal toxicity.6 Clear-HM also contains 25 mg vitamin B6 per daily dose, a necessary co-factor for glutathione synthesis.14
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