Effects of PGX®, a novel functional fibre, on acute and delayed postprandial glycaemia

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Effects of PGX, a novel functional fibre, on acute and delayed postprandial glycaemia

JC Brand-Miller, FS Atkinson, RJ Gahler, V Kacinik, MR Lyon3,4 and S Wood

1Boden Institute of Obesity, Nutrition and Exercise and the School of Molecular Bioscience, University of Sydney, Sydney, NSW, Australia;  2Factors Group R & D, Burnaby, BC, Canada; 3University of British Columbia, Food, Nutrition and Health Program, Vancouver, BC, Canada; 4Canadian Centre for Functional Medicine, Coquitlam, BC, Canada and 5InovoBiologic Inc., Calgary, AB, Canada

Background: Viscous fibre in food has established health benefits, but few functional fibre preparations are both effective and palatable. Our objective was to determine the most effective dose, formulation and timing of consumption of a novel fibre supplement (PolyGlycopleX (PGX)) in reducing postprandial glycaemia.

Subjects/methods: Three trials were undertaken, each with 10 subjects (8M and 8F; age 24.4±2.6 years). Granular supplement was tested at four doses (0, 2.5, 5.0 and 7.5 g) with breakfast (study 1). Granular and capsule forms of the supplement were given in a single dose (5 g for granules and 4.5 g in capsules) at 60, 45, 30, 15 and 0 before, and þ15 min after a bread meal (study 2). Capsules at increasing doses (1.5, 3, 4.5 and 6 g) were consumed with the evening meal to determine effects on glucose tolerance at breakfast (study 3). Incremental area under the blood glucose curve was determined.

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